The Thomas family is one of the local lower middle class families of Greenpoint. They seem to be close friends with the McFarland Family for whom Amanda (called "Mandy") works as a housekeeper. She often brings her son, Buckwheat Thomas with her to the McFarland house. Spanky McFarland impersonates Buckwheat in Anniversary Trouble, and Buckwheat becomes close friends with Spanky's little brother, Porky. Joe Thomas works as a bootblack in town shining shoes for a living and sharing his corner with Grandpa Gus in The Lucky Corner. Amanda is also seen attending her son's Arbor Day presentation at Greenpoint Grammar School. Big Shot appears in the Thomas home in Helping Hands and around the neighborhood in a few other episodes. Buckwheat also mentions having a relative he calls "Uncle Big-Mouth" in Radio Bugs.
- Father - Joe Thomas - Joe Mathey in The Lucky Corner
- Mother - Amanda Thomas - Hattie McDaniel in Anniversary Trouble and Arbor Day, Willa Mae Curtis in Tale Of A Dog, Whoopi Goldberg in The Little Rascals
- Possible Daughter - Real Name? - Carlena Beard in For Pete's Sake, Willie Mae Taylor in The First Round-Up, Honky Donkey, and Washee Ironee
- Son - Buckwheat Thomas - William Thomas Jr. in Mama's Little Pirate to Tale Of A Dog
- Son - Big Shot Thomas in 1-2-3 Go!, Helping Hands, Going To Press, and Unexpected Riches