Smallpox is a terrier originally belonging to Big Shot. Unable to afford to feed the dog and unwilling to turn it in to the dog pound, Big Shot is about to put the pet "Alabamy-bound" on a freight train, when Buckwheat convinces him to give the dog to the gang. When Big Shot informs Buckwheat the spotted dog has no name, Buckwheat suggests "Smallpox," which the dog likes. They bring Smallpox to the gang's clubhouse and discuss plans to share him with Mickey, Janet and Froggy. However, when the latter three overhear the name "Smallpox" they jump to the ridiculous conclusion that there is a viral outbreak that Big Shot and Buckwheat are deliberately spreading. After much distress and worry in town, Smallpox is re-named "Spotty."