Settles-itt Powders is a local brand antacid, possibly available at Bacon's Pharmacy and other local Greenpoint drugstores. Mr. Switzer gives it to Alfalfa to settle his stomach when Alfalfa complains he has no appetite at breakfast. Later, Alfalfa recognizes the powder as ingredients in Butch's supposed dynamite. Trying to impress Darla and show up Butch, Alfalfa ingests the two component solutions separately, which causes his stomach to expand enormously. The instructions say the two powder solutions must be mixed before swallowing.